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KMID : 0614620030410050335
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Korean Journal of Gastroenterology
2003 Volume.41 No. 5 p.335 ~ p.342
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Loss of Fas Expression in Gastric Cancer: Correlation with Clinicopathologic Parameters.
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Song Byung-Joo
Kim Ji-Il
Kim Han-Seong
Park Sung-Hye
Chang Surk-Hyo
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Abstract
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Background/Aims: The Fas-FasL system is the main pathway for the induction of apoptosis in normal and malignant tumor cells. The binding of FasL in the cytotoxic T lymphocytes or Anti-Fas antibody to Fas receptor in cell membrane induces apoptosis. Loss of Fas expression has been demonstrated in a variety of tumor cells. Recently, it is reported that gastric cancers express Fas ligand and downregulate Fas to escape from the host immune surveillance.
Methods: We performed clinicopathological and immunohistochemical studies for Fas, FasL, P53, E-cadherin, beta-catenin, and Ki-67 in the specimens obtained from 52 gastric cancer patients treated with curative resections from 2000 to 2002.
Results: Loss of Fas and expression of FasL were observed in 15 (28.8%) and 19 (36.5%) patients respectively. The loss of Fas expression was dominantly demonstrated in poorly differentiated and diffuse type of gastric carcinoma. Loss of Fas expression had a significant correlation with nuclear expression of beta-catenin (p=0.027).
Conclusions: Loss of Fas expression in gastric cancer is significantly influenced by histological grade, Lauren classification, and nuclear expression of beta-catenin. These findings indicate that loss of Fas expression correlates with aggressiveness of gastric cancer.
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